Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 13/20 | 0.48 |
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18483960 | 0.79 | JAK1 (0.58) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL13031229 | 0.76 | TYK2 (0.76) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL42847 | 0.76 | JAK1 (0.59) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL2237598 | 0.76 | JAK1 (0.60) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL2238798 | 0.74 | JAK1 (0.66) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL29469323 | 0.74 | TYK2 (0.58) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL29469373 | 0.74 | TYK2 (0.58) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL29469335 | 0.73 | TYK2 (0.55) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL11916700 | 0.70 | JAK1 (0.69) | TYK2JAK1JAK2JAK3IKBKB | |
| SCHEMBL13031573 | 0.69 | JAK2 (0.73) | TYK2JAK1JAK2JAK3IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |