SCHEMBL29475674

SCHEMBL29475674

CCCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(CN4CCCCC4)cc3)c2n1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.79
IL6 P05231 6/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1146575 1.00 TLR7 (0.79) TLR7IL6
SCHEMBL12800829 0.96 TLR7 (0.76) TLR7IL6
SCHEMBL1146336 0.91 TLR7 (0.80) TLR7IL6
SCHEMBL1146510 0.91 TLR7 (0.66) TLR7IL6
SCHEMBL1146212 0.91 TLR7 (0.79) TLR7IL6
SCHEMBL12800886 0.91 TLR7 (0.76) TLR7IL6
SCHEMBL12800186 0.91 TLR7 (0.76) TLR7IL6
SCHEMBL12800359 0.91 TLR7 (0.70) TLR7IL6
SCHEMBL15177549 0.91 TLR7 (0.70) TLR7IL6
SCHEMBL1146255 0.90 TLR7 (0.76) TLR7IL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119455003-A Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2025-02-18 CN disclosed
CN-119455004-A Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2025-02-18 CN disclosed
CN-113660957-B Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2024-12-13 CN disclosed
CN-116457023-A antibody-TLR agonist conjugates, methods and uses thereof AMBRX公司 2023-07-18 CN disclosed
EP-4199968-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF Ambrx, Inc. (US) 2023-06-28 EP disclosed
WO-2022040596-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2022-02-24 WO disclosed