Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | GCG | P01275 | 3/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480456 | 0.87 | GCG (0.33) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL29480552 | 0.87 | GRM4 (0.35) | JAK2JAK1GRM4GCG | |
| SCHEMBL22736484 | 0.87 | GRM4 (0.35) | JAK2JAK1GRM4GCG | |
| SCHEMBL29480483 | 0.86 | JAK2 (0.36) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL29480507 | 0.86 | GCG (0.32) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL29480518 | 0.85 | GRM4 (0.32) | JAK2JAK1GRM4GCGGCGR | |
| SCHEMBL29480476 | 0.85 | GCG (0.35) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL29480574 | 0.85 | JAK1 (0.35) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL29480510 | 0.85 | JAK2 (0.32) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL22716928 | 0.84 | GRM4 (0.33) | JAK2JAK1GRM4GCGGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |