Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | GCG | P01275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736484 | 0.89 | GRM4 (0.35) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL29480552 | 0.89 | GRM4 (0.35) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL29568178 | 0.86 | GRM4 (0.34) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL22736187 | 0.86 | GRM4 (0.34) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL22736011 | 0.86 | GRM4 (0.35) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL29480656 | 0.86 | GRM4 (0.35) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL22735737 | 0.85 | GRM4 (0.35) | GRM4JAK2AURKAAURKBINCENP | |
| SCHEMBL29567952 | 0.85 | GRM4 (0.35) | GRM4JAK2AURKAAURKBINCENP | |
| SCHEMBL22735745 | 0.84 | GRM4 (0.34) | GRM4EGLN1JAK2AURKAAURKB | |
| SCHEMBL22735739 | 0.84 | GRM4 (0.34) | GRM4EGLN1JAK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |