Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | GCG | P01275 | 7/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735768 | 0.89 | JAK1 (0.36) | JAK1GCGJAK2ACACBRET | |
| SCHEMBL29480749 | 0.89 | JAK1 (0.36) | JAK1GCGJAK2ACACBRET | |
| SCHEMBL29480595 | 0.81 | JAK1 (0.40) | JAK1GCGJAK2ACACBRET | |
| SCHEMBL22736198 | 0.81 | JAK1 (0.40) | JAK1GCGJAK2ACACBRET | |
| SCHEMBL22735769 | 0.80 | EGLN1 (0.33) | — | |
| SCHEMBL29480690 | 0.80 | OGA (0.34) | — | |
| SCHEMBL29480665 | 0.78 | RIPK2 (0.33) | GCG | |
| SCHEMBL22716891 | 0.78 | RIPK2 (0.34) | GCGJAK2 | |
| SCHEMBL29480664 | 0.78 | RIPK2 (0.34) | GCGJAK2 | |
| SCHEMBL22716927 | 0.78 | RIPK2 (0.33) | GCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |