Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480672 | 0.85 | JAK2 (0.34) | JAK2 | |
| SCHEMBL22735741 | 0.82 | EGLN1 (0.39) | JAK2GRM4EGLN1 | |
| SCHEMBL29480703 | 0.82 | EGLN1 (0.39) | JAK2GRM4EGLN1 | |
| SCHEMBL29480552 | 0.81 | GRM4 (0.35) | JAK2GRM4EGLN1JAK1 | |
| SCHEMBL22736484 | 0.81 | GRM4 (0.35) | JAK2GRM4EGLN1JAK1 | |
| SCHEMBL29480524 | 0.81 | JAK2 (0.33) | JAK2GRM4JAK1 | |
| SCHEMBL29480562 | 0.81 | JAK2 (0.34) | JAK2GRM4JAK1 | |
| SCHEMBL22736482 | 0.81 | JAK2 (0.40) | JAK2GRM4EGLN1JAK1 | |
| SCHEMBL22716880 | 0.81 | JAK2 (0.40) | JAK2JAK1 | |
| SCHEMBL29480583 | 0.81 | JAK2 (0.40) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |