Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.48 |
| ▸ | NEK2 | P51955 | 2/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.48 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PIR | O00625 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015374 | 1.00 | BRAF (0.66) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL3702167 | 0.89 | BRAF (0.58) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL30313440 | 0.89 | BRAF (0.58) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL15677286 | 0.89 | BRAF (0.53) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL3704338 | 0.89 | BRAF (0.53) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL25447211 | 0.89 | BRAF (0.58) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL13505690 | 0.88 | BRAF (0.52) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL3505940 | 0.88 | CYP2C19 (0.52) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL2354890 | 0.88 | BRAF (0.64) | BRAFCYP2C19CYP2C9RIPK2RAF1 | |
| SCHEMBL3703309 | 0.87 | BRAF (0.51) | BRAFCYP2C19CYP2C9RIPK2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062814-A | Compounds that rapidly accelerate fibrosarcoma protein degradation and related methods of use | 阿维纳斯运营公司 | 2023-11-14 | — | — | CN | disclosed |
| EP-4204418-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-07-05 | — | — | EP | disclosed |
| US-20230145336-A1 | BRAF DEGRADERS | C4 THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4168407-A1 | BRAF DEGRADERS | C4 Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230145336-A1 | BRAF DEGRADERS | BRAF, NRAS, RAF1 | BRAF 1/4885CYP2C19 2658/4885CYP2C9 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.