Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.62 |
| ▸ | IKZF2 | Q9UKS7 | 9/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.51 |
| ▸ | WIZ | O95785 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319777 | 1.00 | CRBN (0.62) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL29158065 | 1.00 | CRBN (0.62) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL29482803 | 1.00 | CRBN (0.62) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL21947846 | 1.00 | CRBN (0.62) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL29482859 | 1.00 | CRBN (0.62) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL26969648 | 0.93 | CRBN (0.59) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL24834119 | 0.93 | CRBN (0.59) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL30680831 | 0.93 | CRBN (0.59) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL24319857 | 0.91 | CRBN (0.61) | CRBNIKZF2CSNK1A1IKZF1WIZ | |
| SCHEMBL21876708 | 0.91 | CRBN (0.61) | CRBNIKZF2CSNK1A1IKZF1WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062814-A | Compounds that rapidly accelerate fibrosarcoma protein degradation and related methods of use | 阿维纳斯运营公司 | 2023-11-14 | — | — | CN | disclosed |
| EP-4204418-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |