Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29486866 | 1.00 | MEN1 (0.47) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL27041273 | 1.00 | MEN1 (0.47) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL27041289 | 1.00 | MEN1 (0.47) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL27057129 | 0.92 | MEN1 (0.49) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL30496286 | 0.92 | TNF (0.56) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL29260841 | 0.92 | TNF (0.56) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL6128121 | 0.79 | KDM4E (0.62) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL27041271 | 0.79 | TNF (0.51) | TNFHDAC3KDRHDAC4HDAC1 | |
| SCHEMBL27041207 | 0.79 | MEN1 (0.47) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL27057164 | 0.79 | TRPV1 (0.48) | MEN1KMT2APOLBTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266248-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022061348-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-03-24 | — | — | WO | disclosed |