Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 14/20 | 0.70 |
| ▸ | KRAS | P01116 | 8/20 | 0.70 |
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041247 | 0.94 | SOS1 (0.71) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041264 | 0.94 | SOS1 (0.71) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486843 | 0.90 | SOS1 (0.65) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486832 | 0.90 | SOS1 (0.65) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29985093 | 0.90 | SOS1 (0.65) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29985070 | 0.90 | SOS1 (0.64) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041294 | 0.89 | SOS1 (0.79) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041292 | 0.89 | SOS1 (0.79) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486862 | 0.89 | SOS1 (0.79) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486867 | 0.89 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022061348-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-03-24 | — | — | WO | disclosed |