Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28578842 | 1.00 | PDE7A (0.55) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL4717250 | 0.92 | PDE7A (0.62) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL23778428 | 0.91 | PDE7A (0.50) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL4263093 | 0.91 | PDE7A (0.50) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL8320710 | 0.88 | AKR1B1 (0.49) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL31191374 | 0.87 | PDE7A (0.55) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL4263460 | 0.84 | IP6K1 (0.51) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL4263461 | 0.84 | IP6K1 (0.51) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL29541573 | 0.83 | AKR1B1 (0.47) | PDE7AAKR1B1PGRPDE3BPDE3A | |
| SCHEMBL5336043 | 0.82 | PDE7A (0.48) | PDE7AAKR1B1PGRPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598912-A1 | POLO LIKE KINASE 4 INHIBITORS | Oric Pharmaceuticals, Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| US-12312339-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2025-05-27 | — | — | US | disclosed |
| US-20240124426-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2024-04-18 | — | — | US | disclosed |
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| CN-117794529-A | POLO-like kinase 4 inhibitors | 欧瑞克制药公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11858915-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230365537-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| CN-115677682-B | Spiro PLK4 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2023-07-18 | — | — | CN | disclosed |
| EP-3283482-B1 | PLK4 INHIBITORS | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124426-A1 | POLO LIKE KINASE 4 INHIBITORS | PLK4, PLK2, PLK3 | PDE7A 1481/4885AKR1B1 1751/4885PGR 1920/4885 |
| US-11858915-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | PDE7A 1481/4885AKR1B1 1751/4885PGR 1920/4885 |
| US-20230365537-A1 | POLO LIKE KINASE 4 INHIBITORS | PLK4, PLK2, PLK3 | PDE7A 1481/4885AKR1B1 1751/4885PGR 1920/4885 |
| US-12312339-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | PDE7A 1481/4885AKR1B1 1751/4885PGR 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.