Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.59 |
| ▸ | AURKA | O14965 | 13/20 | 0.59 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | AURKC | Q9UQB9 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165869 | 1.00 | PLK4 (0.61) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL19990549 | 0.93 | AURKB (0.61) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL19990508 | 0.92 | AURKB (0.63) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL18154682 | 0.92 | AURKB (0.63) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL19990470 | 0.91 | AURKB (0.64) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL19990388 | 0.91 | AURKB (0.58) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL18154834 | 0.89 | PLK4 (0.72) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL19990791 | 0.88 | PLK4 (0.68) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL18154723 | 0.87 | AURKA (0.53) | PLK4AURKBAURKASRCAURKC | |
| SCHEMBL18165868 | 0.86 | AURKA (0.51) | PLK4AURKBAURKASRCAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-B1 | PLK4 INHIBITORS | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-04-06 | — | — | EP | disclosed |