Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.50 |
| ▸ | GSK3B | P49841 | 12/20 | 0.50 |
| ▸ | SRC | P12931 | 8/20 | 0.50 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166041 | 1.00 | AURKA (0.50) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL29487425 | 0.93 | AURKA (0.51) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL19998181 | 0.93 | AURKA (0.51) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL29487420 | 0.91 | AURKA (0.62) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL18166026 | 0.91 | AURKA (0.62) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL18165842 | 0.86 | AURKB (0.64) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL18166051 | 0.84 | AURKB (0.53) | AURKAAURKBGSK3BSRCAURKC | |
| SCHEMBL18166024 | 0.84 | AURKA (0.41) | AURKAAURKBGSK3BSRCJAK2 | |
| SCHEMBL29487448 | 0.84 | AURKA (0.41) | AURKAAURKBGSK3BSRCJAK2 | |
| SCHEMBL18154742 | 0.82 | AURKB (0.66) | AURKAAURKBGSK3BSRCAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-B1 | PLK4 INHIBITORS | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-04-06 | — | — | EP | disclosed |