Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.61 |
| ▸ | GSK3B | P49841 | 11/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.61 |
| ▸ | SRC | P12931 | 8/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165846 | 1.00 | AURKA (0.61) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL29487474 | 0.92 | AURKA (0.51) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL18165868 | 0.92 | AURKA (0.51) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL19990520 | 0.91 | AURKA (0.50) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL29487466 | 0.90 | AURKA (0.59) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL18166023 | 0.90 | AURKA (0.59) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL18154723 | 0.89 | AURKA (0.53) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL19990409 | 0.88 | AURKB (0.49) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL19990599 | 0.88 | AURKA (0.57) | AURKAGSK3BAURKBSRCNTRK1 | |
| SCHEMBL19990549 | 0.88 | AURKB (0.61) | AURKAGSK3BAURKBSRCNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-B1 | PLK4 INHIBITORS | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-04-06 | — | — | EP | disclosed |