Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.65 |
| ▸ | AURKA | O14965 | 10/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.61 |
| ▸ | AURKC | Q9UQB9 | 8/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | ERN1 | O75460 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165844 | 1.00 | PLK4 (0.65) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL18154768 | 0.97 | PLK4 (0.69) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL29487421 | 0.92 | PLK4 (0.79) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL18165892 | 0.92 | PLK4 (0.79) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL19990541 | 0.91 | PLK4 (0.68) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL18154667 | 0.91 | PLK4 (0.78) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL19990645 | 0.90 | PLK4 (0.69) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL18165858 | 0.90 | AURKB (0.59) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL19990635 | 0.89 | PLK4 (0.78) | PLK4AURKAAURKBRIPK1AURKC | |
| SCHEMBL19990791 | 0.89 | PLK4 (0.68) | PLK4AURKAAURKBRIPK1AURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-B1 | PLK4 INHIBITORS | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-04-06 | — | — | EP | disclosed |