Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20483266 | 1.00 | IRAK4 (0.58) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL946897 | 0.90 | IRAK4 (0.68) | IRAK4ALDH1A1HTTSMPD3HSD11B1 | |
| Formic Acid SCHEMBL29488713 | 0.84 | IRAK4 (0.62) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL18048153 | 0.84 | IRAK4 (0.87) | IRAK4LMNAHTTSMN1; SMN2NPC1 | |
| Trifluoroacetic Acid SCHEMBL29977687 | 0.83 | SMPD3 (0.71) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL309036 | 0.80 | IRAK4 (0.58) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL19875264 | 0.79 | IRAK4 (0.66) | IRAK4LMNA | |
| Hydrochloric Acid SCHEMBL31474423 | 0.79 | IRAK4 (0.57) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL30152392 | 0.79 | IRAK4 (0.57) | IRAK4ALDH1A1LMNAHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL30279841 | 0.77 | CDK2 (0.73) | IRAK4ALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371190-B1 | HETEROCYCLIC COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2022-03-30 | — | — | EP | disclosed |