Sugi Predict

Sugi Predict / Compounds / SCHEMBL2948769

SCHEMBL2948769

SCHEMBL2948769

O=C(NS(=O)(=O)c1ccc(N[C@@H](CSc2ccccc2)CN2CCOCC2)c([N+](=O)[O-])c1)c1ccc(N2CCC3(CCCC3)CC2)cc1

nearest known ligand 0.76

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 20/20 0.76
▸ BCL2 P10415 15/20 0.76
▸ BCL2L2 Q92843 2/20 0.67
▸ ALB P02768 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2949013 0.93 BCL2L1 (0.70) BCL2L1BCL2BCL2L2ALB
SCHEMBL2948205 0.91 BCL2L1 (0.72) BCL2L1BCL2BCL2L2ALB
SCHEMBL2944986 0.89 BCL2L1 (0.76) BCL2L1BCL2BCL2L2ALB
SCHEMBL2949517 0.88 BCL2L1 (0.79) BCL2L1BCL2BCL2L2ALB
SCHEMBL4477794 0.87 BCL2L1 (0.86) BCL2L1BCL2BCL2L2ALB
SCHEMBL2943771 0.86 BCL2L1 (0.73) BCL2L1BCL2BCL2L2ALB
SCHEMBL2952092 0.86 BCL2L1 (0.78) BCL2L1BCL2BCL2L2ALB
SCHEMBL4465505 0.86 BCL2L1 (0.88) BCL2L1BCL2BCL2L2ALB
SCHEMBL2947329 0.86 BCL2L1 (0.74) BCL2L1BCL2BCL2L2ALB
SCHEMBL2952415 0.86 BCL2L1 (1.00) BCL2L1BCL2BCL2L2ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6720338-B2 BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL ABBOTT LABORATORIES 2004-04-13 — — US claimed
US-7754886-B2 N-acylsulfonamide apoptosis promoters ABBOTT LABORATORIES (US) 2010-07-13 — — US disclosed
US-20090137585-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ABBOTT LABORATORIES (US) 2009-05-28 — — US disclosed
US-7504512-B2 N-acylsulfonamide apoptosis promoters ABBOTT LABORATORIES (US) 2009-03-17 — — US disclosed
EP-1318978-B1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ABBOTT LAB (US) 2006-02-08 — — EP disclosed
US-20040192681-A1 N-acylsulfonamide apoptosis promoters ABBVIE INC. 2004-09-30 — — US disclosed
US-6720338-B2 BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL ABBOTT LABORATORIES 2004-04-13 — — US disclosed
US-20020086887-A1 N-Acylsulfonamide apoptosis promoters ABBVIE INC. 2002-07-04 — — US disclosed
US-20020055631-A1 N-acylsulfonamide apoptosis promoters ABBOTT LABORATORIES 2002-05-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020086887-A1 N-Acylsulfonamide apoptosis promoters BAX, BCLAF1, BCL2 BCL2L1 5/4885BCL2 3/4885BCL2L2 19/4885
US-20020055631-A1 N-acylsulfonamide apoptosis promoters BAX, BCLAF1, BCL2 BCL2L1 4/4885BCL2 3/4885BCL2L2 18/4885
US-20040192681-A1 N-acylsulfonamide apoptosis promoters BAX, BCLAF1, BCL2 BCL2L1 5/4885BCL2 3/4885BCL2L2 19/4885
US-20090137585-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS BAX, BCL2, BCOR BCL2L1 6/4885BCL2 2/4885BCL2L2 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.