Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 10/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | IDH2 | P48735 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31193329 | 0.94 | GAA (0.78) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2919660 | 0.85 | GAA (0.66) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2923400 | 0.85 | GAA (0.83) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL31355336 | 0.85 | GAA (0.71) | GAAMAPTKDM4ELMNAMAPK1 | |
| SCHEMBL31193347 | 0.83 | GAA (0.65) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2943722 | 0.83 | GAA (0.66) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2921992 | 0.83 | GAA (0.77) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2923964 | 0.83 | BRAF (0.69) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL2921758 | 0.83 | BRAF (0.77) | GAAMAPTKDM4EBRAFLMNA | |
| SCHEMBL14022519 | 0.82 | GAA (0.77) | GAAMAPTKDM4ELMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901748-B1 | ANGIOGENESIS INHIBITORS | ONCALIS AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| EP-1901748-B1 | ANGIOGENESIS INHIBITORS | ONCALIS AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| EP-1765351-B9 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2010-03-24 | — | — | EP | disclosed |
| EP-1765351-B1 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| US-20070149535-A1 | Protein kinase inhibitors | ONCALIS AG (CH) | 2007-06-28 | — | — | US | disclosed |
| US-20070149535-A1 | Protein kinase inhibitors | ONCALIS AG (CH) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149535-A1 | Protein kinase inhibitors | FLT1, ERBB2, ERBB3 | GAA 3677/4885MAPT 3858/4885KDM4E 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.