SCHEMBL29488790

SCHEMBL29488790

CCSc1nc(N)c2[nH]c(=O)n(Cc3ccc(Cl)cc3)c2n1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 15/20 0.65
TLR8 Q9NR97 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18207624 1.00 TLR7 (0.65) TLR7TLR8
SCHEMBL18207355 0.91 TLR7 (0.62) TLR7TLR8
SCHEMBL18207424 0.91 TLR7 (0.65) TLR7TLR8
SCHEMBL29488795 0.91 TLR7 (0.65) TLR7TLR8
SCHEMBL18207495 0.91 TLR7 (0.68) TLR7
SCHEMBL19924616 0.90 TLR7 (0.62) TLR7TLR8
SCHEMBL18207669 0.90 TLR7 (0.62) TLR7TLR8
SCHEMBL18207308 0.88 TLR7 (0.65) TLR7TLR8
SCHEMBL20107050 0.86 TLR7 (0.57) TLR7TLR8
SCHEMBL20107030 0.85 TLR7 (0.56) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715214-B Combination therapy of a TLR7 agonist and an HBV capsid assembly inhibitor 豪夫迈·罗氏有限公司 2022-03-04 CN disclosed