SCHEMBL29488798

SCHEMBL29488798

CCS(=N)(=O)c1nc(N)c2[nH]c(=O)n(Cc3ccc(Cl)cc3)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 1.00
TLR8 Q9NR97 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29608621 1.00 TLR7 (1.00) TLR7TLR8
SCHEMBL19945292 1.00 TLR7 (1.00) TLR7TLR8
SCHEMBL19974084 1.00 TLR7 (1.00) TLR7TLR8
SCHEMBL18207274 1.00 TLR7 (1.00) TLR7TLR8
SCHEMBL18207520 0.93 TLR7 (1.00) TLR7TLR8
SCHEMBL29608734 0.91 TLR7 (1.00) TLR7TLR8
SCHEMBL18207479 0.91 TLR7 (1.00) TLR7TLR8
SCHEMBL19945796 0.91 TLR7 (1.00) TLR7TLR8
SCHEMBL19974055 0.91 TLR7 (1.00) TLR7TLR8
SCHEMBL18207406 0.91 TLR7 (1.00) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715214-B Combination therapy of a TLR7 agonist and an HBV capsid assembly inhibitor 豪夫迈·罗氏有限公司 2022-03-04 CN disclosed