Ceritinib

Ceritinib

SCHEMBL29489147

Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ALKEML4NPM1

The experimentally established mechanism targets of Ceritinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALK known ✓ Q9UM73 20/20 1.00
NPM1 known ✓ P06748 1/20 1.00
EML4 known ✓ Q9HC35 1/20 1.00
INSR P06213 9/20 1.00
KCNH2 Q12809 4/20 1.00
PLK4 O00444 1/20 1.00
BUB1B O60566 1/20 1.00
JAK2 O60674 1/20 1.00
ROCK2 O75116 1/20 1.00
ABL1 P00519 1/20 1.00
EGFR P00533 1/20 1.00
NTRK1 P04629 1/20 1.00
LCK P06239 1/20 1.00
FES P07332 1/20 1.00
LYN P07948 1/20 1.00
RET P07949 1/20 1.00
IGF1R P08069 1/20 1.00
ABCB1 P08183 1/20 1.00
MET P08581 1/20 1.00
ROS1 P08922 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ceritinib SCHEMBL1014329 1.00 ALK (1.00) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL29349781 1.00 ALK (1.00) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL29810752 0.99 ALK (0.98) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL30053881 0.99 ALK (0.98) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL9936675 0.99 ALK (0.98) ALKINSRKCNH2PLK4BUB1B
SCHEMBL1545837 0.97 ALK (0.94) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL17879538 0.95 ALK (0.90) ALKINSRKCNH2PLK4BUB1B
Ceritinib SCHEMBL17879536 0.95 ALK (0.93) ALKINSRKCNH2PLK4BUB1B
SCHEMBL24852882 0.95 ALK (1.00) ALKINSRKCNH2PLK4BUB1B
SCHEMBL1014579 0.94 ALK (0.89) ALKINSRKCNH2PLK4BUB1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4602150-A1 A SCALABLE METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIUM (RPE) CELLS Eyestem Research Private Limited (IN) 2025-08-20 EP claimed
CN-120019141-A Scalable method for generating Retinal Pigment Epithelial (RPE) cells 艾视泰研究私人有限公司 2025-05-16 CN claimed
WO-2024079755-A1 A SCALABLE METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIUM (RPE) CELLS EYESTEM RESEARCH PRIVATE LIMITED (IN) 2024-04-18 WO claimed
WO-2024052931-A1 A PROTOCOL FOR GENERATING NEURAL PROGENITOR CELLS AND IMPLEMENTATIONS THEREOF EYESTEM RESEARCH PRIVATE LIMITED (IN) 2024-03-14 WO claimed
CN-110730678-B Pharmaceutical combination comprising an ALK inhibitor and an SHP2 inhibitor 诺华股份有限公司 2022-07-15 CN claimed
WO-2026090174-A1 COMPOSITIONS FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS AND METHODS FOR THE SYNTHESIS AND USE THEREOF BRYET US, INC. (US) 2026-04-30 WO disclosed
EP-4731792-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING LUNG CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4731793-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING PANCREATIC CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4731199-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING COLORECTAL CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4727534-A1 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING BREAST CANCER Burzynski, Stanislaw R. (US) 2026-04-22 EP disclosed
EP-4720058-A2 BIFUNCTIONAL DEGRADERS AND USES THEREOF Casma Therapeutics, Inc. (US) 2026-04-08 EP disclosed
WO-2025238172-A1 COMBINATIONS OF BRAF AND ALK/TRK INHIBITORS FOR COLORECTAL CANCER GENOME RESEARCH LIMITED (GB) 2025-11-20 WO disclosed
EP-3119423-B1 TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTOR NOVARTIS AG (CH) 2022-12-14 EP disclosed
US-20220365074-A1 METHODS AND SYSTEMS FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES USING pH ANALIZA, INC. (US) 2022-11-17 US disclosed
EP-4051288-A1 ALK INHIBITORS FOR TREATMENT OF ALK-NEGATIVE CANCER AND PLASMA CELL-MEDIATED DISEASES Universitetet I Oslo (NO) 2022-09-07 EP disclosed
CN-114989139-A Process for preparing pyrimidine-2, 4-diamine dihydrochloride 诺华股份有限公司 2022-09-02 CN disclosed
CN-114901289-A ALK inhibitors for the treatment of ALK negative cancers and plasma cell mediated diseases 奥斯陆大学 2022-08-12 CN disclosed
WO-2022165185-A1 CANCER-SELECTIVE TARGET DEGRADATION BY TARGETING GROUP CAGED PROTACS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2022-08-04 WO disclosed
CN-110730678-B Pharmaceutical combination comprising an ALK inhibitor and an SHP2 inhibitor 诺华股份有限公司 2022-07-15 CN disclosed
WO-2022069684-A1 TREATMENT FOR VIRAL INFECTION OSLO UNIVERSITETSSYKEHUS HF (NO) 2022-04-07 WO disclosed