SCHEMBL29489268

CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O

nearest known ligand 0.61

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	CRHR1	P34998	1/20	0.56

▸	CRHR2	Q13324	1/20	0.56

▸	CALCR	P30988	3/20	0.55

▸	AGTR2	P50052	3/20	0.52

▸	AGTR1	P30556	2/20	0.52

▸	BACE1	P56817	1/20	0.52

▸	KEAP1	Q14145	1/20	0.51

▸	NPY2R	P49146	6/20	0.50

▸	NPY4R	P50391	6/20	0.50

▸	NPY5R	Q15761	6/20	0.50

▸	NPY1R	P25929	4/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30296696	0.97	CALCR (0.54)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL29501059	0.88	BACE1 (0.59)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL30363005	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL30362923	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL30362943	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL30363072	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL30761771	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL29693043	0.87	BACE1 (0.58)	CRHR1CRHR2CALCRAGTR2AGTR1
SCHEMBL38663746	0.87	CALCR (0.65)	CRHR1CRHR2CALCRNPY2RNPY4R
SCHEMBL30362915	0.87	CALCR (0.55)	CRHR1CRHR2CALCRAGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20240190952-A1	IL-18 Binding Protein (IL-18BP) and Antibodies for Treating Inflammatory Diseases	AB2 BIO SA (CH)	2024-06-13	—	—	US	disclosed
US-11820817-B2	IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases	AB2 BIO SA (CH)	2023-11-21	—	—	US	disclosed
US-20230250164-A1	IL-18 Binding Protein (IL-18BP) In Inflammatory Diseases	AB2 BIO SA (CH)	2023-08-10	—	—	US	disclosed
US-11530263-B2	IL-18 binding protein (IL-18BP) in inflammatory diseases	AB2 BIO SA (CH)	2022-12-20	—	—	US	disclosed
EP-3978526-A1	IL-18 BINDING PROTEIN (IL-18BP) IN INFLAMMATORY DISEASES	AB2 Bio SA (CH)	2022-04-06	—	—	EP	disclosed