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SCHEMBL29489273

SCHEMBL29489273

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O

nearest known ligand 0.73

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TFPI P10646 1/20 0.73
▸ VIPR1 P32241 4/20 0.66
▸ VIPR2 P41587 6/20 0.63
▸ KISS1R Q969F8 2/20 0.61
▸ PTH1R Q03431 1/20 0.60
▸ ECE1 P42892 1/20 0.60
▸ GLP1R P43220 1/20 0.60
▸ MUS81 Q96NY9 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30176419 0.94 VIPR1 (0.68) TFPIVIPR1VIPR2PTH1RECE1
SCHEMBL30567756 0.94 VIPR1 (0.72) TFPIVIPR1VIPR2ECE1GLP1R
SCHEMBL29519384 0.93 TFPI (0.68) TFPIVIPR1VIPR2PTH1RECE1
SCHEMBL30883219 0.92 TFPI (0.67) TFPIVIPR1GLP1R
SCHEMBL30176441 0.92 TFPI (0.64) TFPIVIPR1VIPR2PTH1RECE1
SCHEMBL30601869 0.92 TFPI (0.79) TFPIVIPR1VIPR2ECE1GLP1R
SCHEMBL30198769 0.91 TFPI (0.65) TFPIVIPR1VIPR2PTH1R
SCHEMBL30220503 0.91 TFPI (0.66) TFPIVIPR1VIPR2PTH1RECE1
SCHEMBL31563800 0.91 VIPR1 (0.73) TFPIVIPR1VIPR2ECE1GLP1R
SCHEMBL30496422 0.91 TFPI (0.71) TFPIVIPR1VIPR2PTH1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240190952-A1 IL-18 Binding Protein (IL-18BP) and Antibodies for Treating Inflammatory Diseases AB2 BIO SA (CH) 2024-06-13 — — US disclosed
US-11926663-B2 IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases AB2 BIO SA (CH) 2024-03-12 — — US disclosed
US-11820817-B2 IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases AB2 BIO SA (CH) 2023-11-21 — — US disclosed
US-20230250164-A1 IL-18 Binding Protein (IL-18BP) In Inflammatory Diseases AB2 BIO SA (CH) 2023-08-10 — — US disclosed
US-11530263-B2 IL-18 binding protein (IL-18BP) in inflammatory diseases AB2 BIO SA (CH) 2022-12-20 — — US disclosed
EP-3978526-A1 IL-18 BINDING PROTEIN (IL-18BP) IN INFLAMMATORY DISEASES AB2 Bio SA (CH) 2022-04-06 — — EP disclosed
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