Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.67 |
| ▸ | PDE2A | O00408 | 3/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.55 |
| ▸ | NT5E | P21589 | 7/20 | 0.52 |
| ▸ | CD99 | P14209 | 1/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22807175 | 1.00 | ADORA2A (0.67) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL19948414 | 0.97 | ADORA2A (0.66) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL30262586 | 0.97 | ADORA2A (0.66) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL10026376 | 0.88 | PDE2A (0.72) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL20350734 | 0.88 | PDE2A (0.72) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL14074362 | 0.88 | PDE2A (0.72) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL14086557 | 0.88 | PDE2A (0.72) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL19961940 | 0.88 | ADORA2A (0.53) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL8971491 | 0.83 | ADORA2A (0.60) | ADORA2APDE2AADORA3ADORA1ADRA1A | |
| SCHEMBL8971472 | 0.83 | ADORA2A (0.60) | ADORA2APDE2AADORA3ADORA1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986894-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | Calithera Biosciences, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |