Famciclovir

Famciclovir

SCHEMBL2949

CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 1.00
ALDH1A1 P00352 1/20 1.00
HPGD P15428 1/20 1.00
ADRA1A P35348 1/20 1.00
HSD17B10 Q99714 1/20 1.00
RXFP1 Q9HBX9 1/20 1.00
HDAC6 Q9UBN7 2/20 0.44
HSP90AA1 P07900 2/20 0.40
HSP90AB1 P08238 1/20 0.40
RPS6KA3 P51812 1/20 0.37
P2RY1 P47900 2/20 0.36
CYP2C19 P33261 1/20 0.35
ADORA2B P29275 2/20 0.33
DUT P33316 1/20 0.33
IRAK4 Q9NWZ3 2/20 0.32
CDK1 P06493 1/20 0.31
CCNB1 P14635 1/20 0.31
CCNE1 P24864 1/20 0.31
CDK2 P24941 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Famciclovir SCHEMBL29357294 1.00 KDM4E (1.00) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL8190642 1.00 KDM4E (1.00) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL6471652 0.99 KDM4E (0.98) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL7103048 0.99 KDM4E (0.98) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL3932051 0.99 KDM4E (0.98) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL29098544 0.99 KDM4E (0.98) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL6471750 0.97 KDM4E (0.94) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL29110632 0.96 KDM4E (0.92) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL2326990 0.95 KDM4E (0.90) KDM4EALDH1A1HPGDADRA1AHSD17B10
Famciclovir SCHEMBL28668832 0.95 KDM4E (0.90) KDM4EALDH1A1HPGDADRA1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 28874 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144816-A1 COMPOSITIONS AND METHODS FOR TREATING DEMENTIA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-05-28 US claimed
US-20260137669-A1 NOVEL ENANTIOMERS OF A SERIES OF ANTIVIRAL COMPOUNDS INNOVATIVE MOLECULES GMBH (DE) 2026-05-21 US claimed
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
EP-4094767-B1 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO UNIV EMORY (US) 2026-05-20 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-3790536-B1 NANOCONTAINERS FOR TRANSPORTING NONPOLAR, LIPOPHILIC SUBSTANCES SUCH AS ANTIBIOTICS KARLSRUHER INST TECHNOLOGIE (DE) 2026-04-22 EP claimed
US-20260102422-A1 4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO UNIV EMORY (US) 2026-04-16 US claimed
US-12595280-B2 Phosphoramidates for the treatment of hepatitis B virus EMORY UNIVERSITY (US) 2026-04-07 US claimed
US-20260092059-A1 Broad Spectrum Antiviral Compositions and Methods EVRYS BIO, LLC (US) 2026-04-02 US claimed
WO-1992013859-A1 PHARMACEUTICALS SMITHKLINE BEECHAM PLC (GB) 1992-08-20 WO claimed
WO-1992013527-A1 WATER-DISPERSIBLE TABLETS THE WELLCOME FOUNDATION LIMITED (GB) 1992-08-20 WO claimed
EP-0493767-A2 Synergistic combination for treating herpes infections BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed
EP-0493770-A2 Antiherpes compositions BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed
WO-1992009287-A1 COMBINATIONS OF VANILLOID COMPOUNDS AND NUCLEOSIDE ANTIVIRAL COMPOUNDS FOR TREATMENT OF HERPES INFECTIONS THE PROCTER & GAMBLE COMPANY (US) 1992-06-11 WO claimed
WO-1992000742-A1 PENCICLOVIR AND FAMCICLOVIR AND RELATED GUANINE DERIVATIVES FOR THE TREATMENT OF THE HIV-1 INFECTIONS BEECHAM GROUP PLC (GB) 1992-01-23 WO claimed
EP-0182024-B1 PURINE DERIVATIVES AND THEIR PHARMACEUTICAL USE BEECHAM GROUP PLC (GB) 1991-04-03 EP claimed
EP-0388049-A2 Derivatives of penciclovir for the treatment of hepatitis-B infections BEECHAM GROUP PLC (GB) 1990-09-19 EP claimed
WO-1987005604-A1 2-AMINOPURINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION BEECHAM GROUP P.L.C. (GB) 1987-09-24 WO claimed
EP-0182024-A2 Purine derivatives and their pharmaceutical use BEECHAM GROUP PLC (GB) 1986-05-28 EP claimed