Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.78 |
| ▸ | KIT | P10721 | 10/20 | 0.78 |
| ▸ | KDR | P35968 | 9/20 | 0.78 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.78 |
| ▸ | LCK | P06239 | 6/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.63 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953078 | 1.00 | MAPK14 (0.78) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952510 | 0.97 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2955274 | 0.97 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2948597 | 0.97 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952544 | 0.89 | MAPK14 (0.68) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3142056 | 0.89 | MAPK14 (0.70) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2945875 | 0.88 | MAPK14 (0.84) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952507 | 0.88 | MAPK14 (0.60) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2956008 | 0.88 | MAPK14 (1.00) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2951620 | 0.88 | MAPK14 (1.00) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759337-B2 | Phthalazine compounds and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-20060199817-A1 | Phthalazine, aza- and diaza-phthalazine compounds and methods of use | AMGEN INC. (US) | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199817-A1 | Phthalazine, aza- and diaza-phthalazine compounds and methods of use | DAPK2, CDK2, DAPK1 | MAPK14 293/4885KIT 1977/4885KDR 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.