Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19469463 | 1.00 | PPARA (0.48) | PPARAAKR1B1MAPK1SRD5A1SRD5A2 | |
| SCHEMBL19469478 | 1.00 | PPARA (0.48) | PPARAAKR1B1MAPK1SRD5A1SRD5A2 | |
| SCHEMBL19469461 | 1.00 | PPARA (0.48) | PPARAAKR1B1MAPK1SRD5A1SRD5A2 | |
| SCHEMBL29495503 | 1.00 | PPARA (0.48) | PPARAAKR1B1MAPK1SRD5A1SRD5A2 | |
| SCHEMBL11362870 | 0.88 | PPARA (0.39) | PPARAAKR1B1SRD5A1SRD5A2DRD2 | |
| SCHEMBL19030472 | 0.88 | AKR1B1 (0.42) | PPARAAKR1B1MAPK1HCAR2 | |
| SCHEMBL23618118 | 0.86 | PPARA (0.47) | PPARALMNA | |
| SCHEMBL19469595 | 0.85 | PPARA (0.46) | PPARASRD5A1SRD5A2CYP2D6CYP2C9 | |
| SCHEMBL19469681 | 0.85 | PPARA (0.46) | PPARASRD5A1SRD5A2CYP2D6CYP2C9 | |
| SCHEMBL19469460 | 0.85 | PPARA (0.46) | PPARASRD5A1SRD5A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3962899-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |