Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.61 |
| ▸ | LCK | P06239 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 11/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947887 | 0.85 | BTK (0.72) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2951251 | 0.84 | BTK (0.61) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2952040 | 0.83 | BTK (0.72) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL14611134 | 0.82 | BTK (0.62) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL13154260 | 0.81 | BTK (0.76) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2941855 | 0.81 | BTK (0.61) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2948801 | 0.81 | BTK (0.77) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2944538 | 0.81 | BTK (0.69) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2945518 | 0.80 | BTK (0.62) | BTKLCKKDRMAPK14KIT | |
| SCHEMBL2943817 | 0.79 | BLK (0.58) | BTKLCKKDRMAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754717-B2 | Bis-aryl amide compounds and methods of use | AMGEN INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070072862-A1 | Bis-aryl amide compounds and methods of use | AMGEN INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072862-A1 | Bis-aryl amide compounds and methods of use | LCK, BTK, IRAK1 | BTK 2/4885LCK 1/4885KDR 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.