SCHEMBL2949608

SCHEMBL2949608

CC(C)(N)CNC(=O)c1ccc(NC(=O)Cc2ccc(Br)c(Oc3cc(Cl)cc(C#N)c3)c2F)c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.36
KCNH2 Q12809 2/20 0.34
ANO1 Q5XXA6 1/20 0.33
PDK1 Q15118 4/20 0.32
PDK2 Q15119 4/20 0.32
PDK3 Q15120 4/20 0.32
PDK4 Q16654 4/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
RORC P51449 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
AR P10275 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
DDR1 Q08345 3/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31
EPHX2 P34913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2942854 0.89 CYP3A4 (0.38) CYP3A4KCNH2ANO1PDK1PDK2
SCHEMBL2950724 0.88 CYP3A4 (0.38) CYP3A4KCNH2ANO1PDK1PDK2
SCHEMBL2944457 0.86 CYP3A4 (0.36) CYP3A4KCNH2PDK1PDK2PDK3
SCHEMBL2951433 0.86 CYP3A4 (0.36) CYP3A4KCNH2CA12CA1CA2
SCHEMBL2944696 0.86 CYP3A4 (0.36) CYP3A4KCNH2ANO1CA12CA1
SCHEMBL2950902 0.85 CYP3A4 (0.37) CYP3A4KCNH2ANO1RORCCYP2C9
SCHEMBL2942807 0.85 KCNH2 (0.35) CYP3A4KCNH2CA12CA1CA2
SCHEMBL2944695 0.85 CYP3A4 (0.38) CYP3A4KCNH2ANO1CA12CA1
SCHEMBL2945361 0.84 CYP3A4 (0.34) CYP3A4KCNH2PDK1PDK2PDK3
SCHEMBL2948154 0.84 CYP3A4 (0.36) CYP3A4KCNH2ANO1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7754919-B2 Non-nucleoside reverse transcriptase inhibitors ROCHE PALO ALTO LLC (US) 2010-07-13 US claimed
EP-1940782-B1 N-PHENYL PHENYLACETAMIDE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-03-11 EP claimed
EP-1940782-A1 N-PHENYL PHENYLACETAMIDE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INIHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2008-07-09 EP claimed
WO-2007045572-A1 N-PHENYL PHENYLACETAMIDE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INIHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2007-04-26 WO claimed
EP-1940782-B1 N-PHENYL PHENYLACETAMIDE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-03-11 EP disclosed