Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 1.00 |
| ▸ | CSNK1D | P48730 | 1/20 | 1.00 |
| ▸ | PARP1 | P09874 | 18/20 | 0.82 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51064 | 1.00 | PIM1 (1.00) | PIM1CSNK1DPARP1ROCK1 | |
| SCHEMBL61589 | 0.92 | PIM1 (0.85) | PIM1CSNK1DPARP1 | |
| SCHEMBL51663 | 0.92 | PIM1 (0.85) | PIM1CSNK1DPARP1 | |
| SCHEMBL1319786 | 0.91 | PIM1 (0.84) | PIM1CSNK1DPARP1 | |
| SCHEMBL14336521 | 0.91 | PARP1 (0.83) | PIM1CSNK1DPARP1ROCK1 | |
| SCHEMBL61587 | 0.91 | PARP1 (0.83) | PIM1CSNK1DPARP1 | |
| SCHEMBL10035767 | 0.91 | PIM1 (0.82) | PIM1CSNK1DPARP1 | |
| SCHEMBL51776 | 0.90 | PIM1 (0.82) | PIM1CSNK1DPARP1 | |
| SCHEMBL61766 | 0.90 | PARP1 (0.82) | PIM1CSNK1DPARP1 | |
| SCHEMBL22674578 | 0.90 | PARP1 (0.82) | PIM1CSNK1DPARP1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220098196-A1 | TRAPPING-FREE PARP INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-03-31 | — | — | US | claimed |
| CN-118973617-A | Conjugates, compositions, and methods of use | 维尔托索宾科公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-4460330-A1 | CONJUGATES, COMPOSITIONS AND METHODS OF USE | Virtuoso Binco, Inc. (US) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023131219-A1 | CONJUGATES, COMPOSITIONS AND METHODS OF USE | VIRTUOSO BINCO, INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| US-20230065522-A1 | METHODS OF CANCER DETECTION USING PARPI-FL | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2023-03-02 | — | — | US | disclosed |
| US-20220098196-A1 | TRAPPING-FREE PARP INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230065522-A1 | METHODS OF CANCER DETECTION USING PARPI-FL | PARP2, PARP1, PARP3 | PIM1 1871/4885CSNK1D 2049/4885PARP1 2/4885 |
| US-20220098196-A1 | TRAPPING-FREE PARP INHIBITORS | PARP1, PARP3, PARP11 | PIM1 447/4885CSNK1D 2610/4885PARP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.