Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.81 |
| ▸ | FAP | Q12884 | 3/20 | 0.57 |
| ▸ | POU2F2 | P09086 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | POU2F1 | P14859 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.57 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.57 |
| ▸ | GHSR | Q92847 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19154424 | 0.92 | DPP4 (0.77) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL8354330 | 0.91 | DPP4 (0.69) | DPP4CHRM1 | |
| SCHEMBL19170393 | 0.91 | DPP4 (0.77) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL196652 | 0.90 | DPP4 (1.00) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL196653 | 0.90 | DPP4 (1.00) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL29800971 | 0.90 | DPP4 (1.00) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL13485028 | 0.88 | DPP4 (0.64) | DPP4CHRM1 | |
| SCHEMBL13911695 | 0.88 | DPP4 (0.64) | DPP4CHRM1 | |
| SCHEMBL24508878 | 0.87 | DPP4 (0.79) | DPP4CHRM1FAPPOU2F2ADORA3 | |
| SCHEMBL8349842 | 0.87 | DPP4 (0.63) | DPP4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9713618-B2 | Method for modifying food intake and regulating food preference with a DPP-4 inhibitor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-07-25 | — | — | US | disclosed |
| US-8232281-B2 | Uses of DPP-IV inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-31 | — | — | US | disclosed |
| US-20120165251-A1 | Diabetes therapy | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20120003313-A1 | DPP IV INHIBITOR FORMULATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110190322-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| US-20110098240-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A SGLT2 INHIBITOR IN COMBINATION WITH A DPP-IV INHIBITOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | US | disclosed |
| US-20110092510-A1 | DPP-IV INHIBITORS FOR USE IN THE TREATMENT OF NAFLD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-21 | — | — | US | disclosed |
| US-20110065731-A1 | USES OF DPP-IV INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-17 | — | — | US | disclosed |
| EP-2023902-B1 | DPP IV INHIBITOR FORMULATIONS | BOEHRINGER INGELHEIM INT (DE) | 2010-09-08 | — | — | EP | disclosed |
| US-7667035-B2 | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-23 | — | — | US | disclosed |
| EP-1569936-B1 | NOVEL SUBSTITUTED IMIDAZO-PYRIDINONES AND IMIDAZO-PYRIDAZEIONES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-03-18 | — | — | EP | disclosed |
| US-20090023920-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INTERMEDIATES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS AND PESTICIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-22 | — | — | US | disclosed |
| US-7439370-B2 | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-21 | — | — | US | disclosed |
| US-20070281940-A1 | USES OF DPP-IV INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
| WO-2004050658-A1 | NOVEL SUBSTITUTED IMIDAZO-PYRIDINONES AND IMIDAZO-PYRIDAZEIONES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092510-A1 | DPP-IV INHIBITORS FOR USE IN THE TREATMENT OF NAFLD | DPP4, DPP3, DPP7 | DPP4 1/4885CHRM1 3696/4885FAP 25/4885 |
| US-20070281940-A1 | USES OF DPP-IV INHIBITORS | DPP4, DPP3, DPP7 | DPP4 1/4885CHRM1 2215/4885FAP 13/4885 |
| US-20120165251-A1 | Diabetes therapy | DPP4, DPP3, DPP7 | DPP4 1/4885CHRM1 2895/4885FAP 113/4885 |
| US-20110065731-A1 | USES OF DPP-IV INHIBITORS | DPP4, DPP3, DPP7 | DPP4 1/4885CHRM1 2215/4885FAP 13/4885 |
| US-20110098240-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A SGLT2 INHIBITOR IN COMBINATION WITH A DPP-IV INHIBITOR | SLC5A1, SLC5A2, DPP4 | DPP4 3/4885CHRM1 3573/4885FAP 413/4885 |
| US-20120003313-A1 | DPP IV INHIBITOR FORMULATIONS | DPP4, DPP3, DPP7 | DPP4 1/4885CHRM1 4517/4885FAP 26/4885 |
| US-20110190322-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | DPP4, DPP7, DPP3 | DPP4 1/4885CHRM1 4554/4885FAP 12/4885 |
| US-20090023920-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INTERMEDIATES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS AND PESTICIDES | CHRM1, CHRM2, CYP3A43 | DPP4 774/4885CHRM1 1/4885FAP 3938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.