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SCHEMBL29499162

SCHEMBL29499162

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CALCR P30988 4/20 0.61
▸ BACE1 P56817 1/20 0.60
▸ NPY2R P49146 8/20 0.57
▸ NPY4R P50391 8/20 0.57
▸ NPY5R Q15761 8/20 0.57
▸ NPY1R P25929 6/20 0.57
▸ CRHR1 P34998 1/20 0.56
▸ CRHR2 Q13324 1/20 0.56
▸ AGTR1 P30556 1/20 0.53
▸ AGTR2 P50052 1/20 0.53
▸ TFPI P10646 2/20 0.53
▸ NTSR1 P30989 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30363034 0.98 BACE1 (0.60) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL29835097 0.98 CALCR (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30362874 0.98 CALCR (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL29501059 0.97 BACE1 (0.59) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30363072 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL29626845 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30761771 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30362923 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30362943 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R
SCHEMBL30363122 0.97 BACE1 (0.58) CALCRBACE1NPY2RNPY4RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240124889-A1 COMPOSITIONS AND METHODS FOR THE VECTORED AUGMENTATION OF PROTEIN DESTRUCTION, EXPRESSION AND/OR REGULATION VOYAGER THERAPEUTICS, INC. 2024-04-18 — — US disclosed
CN-116162128-A Nucleoside derivative for resisting virus infection and preparation method and application thereof 知和(山东)大药厂有限公司 2023-05-26 — — CN disclosed
US-20230075314-A1 VECTORIZED ANTIBODIES (vAb) AND USES THEREOF VOYAGER THERAPEUTICS, INC. 2023-03-09 — — US disclosed
US-20220395544-A1 COMPOSITIONS FOR THE TREATMENT OF DISEASE VOYAGER THERAPEUTICS, INC. (US) 2022-12-15 — — US disclosed
US-11299751-B2 Compositions for the treatment of disease VOYAGER THERAPEUTICS, INC. (US) 2022-04-12 — — US disclosed
EP-3966227-A1 COMPOSITIONS AND METHODS FOR THE VECTORED AUGMENTATION OF PROTEIN DESTRUCTION, EXPRESSION AND/OR REGULATION Voyager Therapeutics, Inc. (US) 2022-03-16 — — EP disclosed
EP-3963055-A1 VECTORIZED ANTIBODIES (VAB) AND USES THEREOF Voyager Therapeutics, Inc. (US) 2022-03-09 — — EP disclosed
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