Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12561159 | 1.00 | MAOB (0.56) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL22617253 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL4931666 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL29540680 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL29540767 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL4936889 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL29364688 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL22617257 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL22617487 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL1533015 | 0.86 | MAOB (0.60) | MAOBADORA3ARKDM4ECYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-114206848-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-03-18 | — | — | CN | disclosed |