Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744881 | 1.00 | EGFR (0.52) | EGFRMAPK1MAPK3MAP2K1LRRK2 | |
| SCHEMBL28744826 | 0.86 | MAPK1 (0.47) | EGFRMAPK1MAPK3MAP2K1 | |
| SCHEMBL28744905 | 0.80 | CDK19 (0.57) | EGFRMAPK1MAP2K1AURKA | |
| SCHEMBL29499593 | 0.80 | CDK19 (0.57) | EGFRMAPK1MAP2K1AURKA | |
| SCHEMBL28744854 | 0.77 | EGFR (0.52) | EGFRMAPK1LRRK2AURKAIGF1R | |
| SCHEMBL29499581 | 0.77 | EGFR (0.52) | EGFRMAPK1LRRK2AURKAIGF1R | |
| SCHEMBL22673978 | 0.76 | LRRK2 (0.53) | MAPK1MAPK3MAP2K1LRRK2IGF1R | |
| SCHEMBL28744819 | 0.74 | EGFR (0.48) | EGFRAURKA | |
| SCHEMBL29499601 | 0.74 | EGFR (0.48) | EGFRAURKA | |
| SCHEMBL1706135 | 0.73 | EGFR (0.72) | EGFRMAPK1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276331-B | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114276331-A | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2022-04-05 | — | — | CN | disclosed |