Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | GFER | P55789 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033840 | 0.83 | MAPT (0.63) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL29847798 | 0.77 | KDM4E (0.73) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL8806485 | 0.77 | KDM4E (0.73) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL31289478 | 0.76 | KDM4E (0.76) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL14447528 | 0.75 | KDM4E (0.57) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL7033846 | 0.73 | MAPT (0.82) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| Dimethylamine SCHEMBL16741824 | 0.72 | KDM4E (0.68) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL22091286 | 0.68 | MAPT (0.94) | KDM4EMAPTGFERRAB9AALDH1A1 | |
| SCHEMBL22982922 | 0.67 | PARP1 (0.56) | KDM4EMAPTGFERSMN1; SMN2KMT2A | |
| SCHEMBL31289521 | 0.67 | MEN1 (0.56) | KDM4EMAPTGFERRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3339305-B1 | INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN PHARMACEUTICAL DRUG | ZHEJIANG HISUN PHARM CO LTD (CN) | 2022-05-04 | — | — | EP | disclosed |