Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.45 |
| ▸ | STS | P08842 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16044951 | 0.91 | CYP19A1 (0.45) | CYP19A1STSCYP11B1PIK3CAPIK3CD | |
| SCHEMBL29501246 | 0.88 | CYP19A1 (0.48) | CYP19A1STSPIK3CAPIK3CDPIK3CB | |
| SCHEMBL16046480 | 0.87 | CYP19A1 (0.44) | CYP19A1STSCYP11B1PIK3CAGRIN1 | |
| SCHEMBL16114228 | 0.87 | CYP19A1 (0.58) | CYP19A1STSPDE4B | |
| SCHEMBL29501245 | 0.87 | CYP19A1 (0.58) | CYP19A1STSPDE4B | |
| SCHEMBL20356874 | 0.85 | GRIN1 (0.42) | CYP19A1STSGRIN1GRIN2BPDE4B | |
| SCHEMBL16113024 | 0.82 | CYP19A1 (0.45) | CYP19A1CYP11B1PIK3CAGRIN1GRIN2B | |
| SCHEMBL29501215 | 0.82 | CYP19A1 (0.45) | CYP19A1CYP11B1PIK3CAGRIN1GRIN2B | |
| SCHEMBL16113268 | 0.80 | HDAC1 (0.41) | CYP11B1GRIN1GRIN2BPDE4B | |
| SCHEMBL16046743 | 0.80 | PIK3CA (0.42) | CYP19A1PIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122172-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | DART NEUROSCIENCE LLC | 2025-04-17 | — | — | US | disclosed |
| US-20230075774-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2023-03-09 | — | — | US | disclosed |
| US-11279691-B2 | Substituted pyridine and pyrazine compounds as PDE4 inhibitors | DART NEUROSCIENCE LLC (US) | 2022-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122172-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4D | CYP19A1 2066/4885STS 4308/4885CYP11B1 795/4885 |
| US-20230075774-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4D | CYP19A1 2066/4885STS 4308/4885CYP11B1 795/4885 |
| US-11279691-B2 | Substituted pyridine and pyrazine compounds as PDE4 inhibitors | PDE4A, PDE4B, PDE4D | CYP19A1 2107/4885STS 4307/4885CYP11B1 804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.