SCHEMBL29501415

SCHEMBL29501415

Fc1cccc(Nc2cc(N3CCC(N4CCc5ccccc5C4)CC3)ncn2)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.53
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
LMNA P02545 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
MAPK10 P53779 1/20 0.47
KMT2A Q03164 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CHRM4 P08173 8/20 0.45
CHRM2 P08172 2/20 0.41
CHRM5 P08912 2/20 0.41
CHRM1 P11229 2/20 0.41
CHRM3 P20309 2/20 0.41
ADRA1A P35348 2/20 0.39
CXCR3 P49682 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
HRH4 Q9H3N8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29501470 0.96 SCN9A (0.50) SCN9AKDM4EMEN1LMNAMAPK1
SCHEMBL26249666 0.96 SCN9A (0.50) SCN9AKDM4EMEN1LMNAMAPK1
SCHEMBL26248704 0.92 SCN9A (0.48) SCN9ACHRM4CHRM2CHRM5CHRM1
SCHEMBL29501439 0.92 SCN9A (0.48) SCN9ACHRM4CHRM2CHRM5CHRM1
SCHEMBL29501346 0.90 SCN9A (0.48) SCN9AMAPK1SMN1; SMN2CHRM4CHRM2
SCHEMBL26248210 0.90 SCN9A (0.48) SCN9AMAPK1SMN1; SMN2CHRM4CHRM2
SCHEMBL26248126 0.90 SCN9A (0.53) SCN9ACHRM4CHRM2CHRM5CHRM1
SCHEMBL25387637 0.89 SCN9A (0.54) SCN9AKDM4EMEN1LMNAMAPK1
SCHEMBL25387632 0.89 SCN9A (0.54) SCN9AKDM4EMEN1LMNAMAPK1
SCHEMBL26249672 0.89 SCN9A (0.54) SCN9AKDM4EMEN1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022048631-A1 COMPOUND HAVING ANTITUMOR ACTIVITY AND USE THEREOF 上海翊石医药科技有限公司 2022-03-10 WO disclosed