⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1208235 | 0.82 | — | — | |
| SCHEMBL180596 | 0.75 | — | — | |
| SCHEMBL141255 | 0.75 | HSD17B10 (0.44) | — | |
| SCHEMBL3955091 | 0.72 | — | — | |
| SCHEMBL8729 | 0.72 | — | — | |
| Ammonia Solution, Strong SCHEMBL6053342 | 0.72 | — | — | |
| SCHEMBL3950444 | 0.72 | — | — | |
| SCHEMBL18507037 | 0.72 | HSD17B10 (0.48) | — | |
| SCHEMBL20055717 | 0.72 | HSD17B10 (0.42) | — | |
| SCHEMBL7598 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107438607-A | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | 因赛特公司 | 2017-12-05 | — | — | CN | claimed |
| US-20110257181-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-10-20 | — | — | US | claimed |
| EP-2367815-A1 | PYRIDAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010072296-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | WO | claimed |
| CN-101573121-A | Modulators of muscarinic receptors | VERTEX PHARMA (US) | 2009-11-04 | — | — | CN | claimed |
| CN-101146795-A | Pyrazole derivatives for the inhibition of CDK and GSK | ASTEX THERAPEUTICS LTD (GB) | 2008-03-19 | — | — | CN | claimed |
| US-20070060558-A1 | Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents | PALUMED S.A. (FR) | 2007-03-15 | — | — | US | claimed |
| EP-0131374-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PENEM DERIVATIVES | PFIZER INC. (US) | 1988-11-23 | — | — | EP | claimed |
| US-4619783-A | BACTERICIDES | PFIZER INC. (US) | 1986-10-28 | — | — | US | claimed |
| EP-0131374-A1 | Process and intermediates for the preparation of penem derivatives | PFIZER INC. (US) | 1985-01-16 | — | — | EP | claimed |
| CN-109641918-A | Imidazoles as inhibitors of histone demethylases | 欧洲肿瘤研究所有限责任公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-109503463-A | A kind of synthetic method of nitrogen-(piperidin-4-yl) -2- (trifluoromethyl) benzamide hydrochloride salt | 无锡合全药业有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-108794485-A | A kind of toll samples receptor modulators, its pharmaceutical composition, preparation method and purposes | 北京施安泰医药技术开发有限公司 | 2018-11-13 | — | — | CN | disclosed |
| EP-2367815-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-20140031334-A1 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-01-30 | — | — | US | disclosed |
| CN-1057269-A | Peptide compounds and preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-25 | — | — | CN | disclosed |
| EP-0131374-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PENEM DERIVATIVES | PFIZER INC. (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4619783-A | BACTERICIDES | PFIZER INC. (US) | 1986-10-28 | — | — | US | disclosed |
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |
| EP-0131374-A1 | Process and intermediates for the preparation of penem derivatives | PFIZER INC. (US) | 1985-01-16 | — | — | EP | disclosed |