Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | LYN | P07948 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379508 | 1.00 | KDR (0.41) | KDRAURKAAURKBEPHB4MAPT | |
| SCHEMBL4764241 | 0.79 | KDR (0.40) | KDRAURKAAURKBEPHB4PLK4 | |
| SCHEMBL18341971 | 0.79 | KDR (0.40) | KDRAURKAAURKBEPHB4PLK4 | |
| SCHEMBL13764546 | 0.78 | KDR (0.40) | KDRAURKAAURKBEPHB4MAPT | |
| SCHEMBL868356 | 0.76 | KDR (0.57) | KDRAURKAAURKBEPHB4HIPK2 | |
| SCHEMBL30958677 | 0.76 | KDR (0.38) | KDRAURKAAURKBEPHB4SMN1; SMN2 | |
| SCHEMBL17176672 | 0.76 | KDR (0.38) | KDRAURKAAURKBEPHB4SMN1; SMN2 | |
| SCHEMBL29503401 | 0.76 | KDR (0.57) | KDRAURKAAURKBEPHB4HIPK2 | |
| SCHEMBL3785902 | 0.72 | CSNK2A1 (0.37) | KDRAURKAAURKBEPHB4SMN1; SMN2 | |
| SCHEMBL18341898 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311894-B | N- (substituted-phenyl) -sulfonamide derivatives as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2022-03-22 | — | — | CN | disclosed |