Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fiboflapon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP known ✓ | P20292 | 20/20 | 0.99 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.99 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.99 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.99 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fiboflapon SCHEMBL29379276 | 0.99 | ALOX5AP (1.00) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| Fiboflapon SCHEMBL29723363 | 0.99 | ALOX5AP (1.00) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| Fiboflapon SCHEMBL11820 | 0.99 | ALOX5AP (1.00) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| Fiboflapon SCHEMBL1254873 | 0.99 | ALOX5AP (0.99) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| Fiboflapon SCHEMBL28358195 | 0.99 | ALOX5AP (0.99) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| Fiboflapon SCHEMBL4365681 | 0.95 | ALOX5AP (0.89) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| SCHEMBL12526775 | 0.94 | ALOX5AP (0.90) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| SCHEMBL167903 | 0.94 | ALOX5AP (0.90) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| SCHEMBL1394760 | 0.93 | ALOX5AP (0.88) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 | |
| SCHEMBL29063029 | 0.93 | ALOX5AP (0.88) | ALOX5APPTGS1ALOX5LTC4SCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110785420-B | Oxazepin derivatives as inhibitors of PI 3-kinase activity | 葛兰素史克知识产权开发有限公司 | 2022-04-26 | — | — | CN | disclosed |