Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 10/20 | 0.59 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.56 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.56 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596001 | 1.00 | IL2 (0.59) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL12181709 | 0.88 | MEN1 (0.53) | STIM1ORAI1ORAI2RAB9ANPC1 | |
| SCHEMBL14887381 | 0.86 | IL2 (0.56) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL1701649 | 0.86 | STIM1 (0.67) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL2595935 | 0.83 | SMO (0.55) | RAB9ANPC1SMN1; SMN2MAPTJAK2 | |
| SCHEMBL16017229 | 0.81 | NPC1 (0.47) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL12181716 | 0.80 | STIM1 (0.52) | STIM1ORAI1ORAI2RAB9ANPC1 | |
| SCHEMBL1825939 | 0.79 | IL2 (0.76) | IL2RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL15164981 | 0.79 | IL2 (0.56) | IL2RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL15164987 | 0.79 | IL2 (0.56) | IL2RAB9ANPC1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563759-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2022-04-06 | — | — | EP | disclosed |