Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 4/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 8/20 | 0.51 |
| ▸ | CCND1 | P24385 | 8/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | WEE1 | P30291 | 3/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 6/20 | 0.48 |
| ▸ | CCND3 | P30281 | 6/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21373314 | 1.00 | TNK2 (0.59) | TNK2JAK2BRD4CDK4CCND1 | |
| SCHEMBL21373432 | 0.80 | CDK4 (0.54) | TNK2JAK2BRD4CDK4CCND1 | |
| SCHEMBL21373277 | 0.79 | CDK4 (0.55) | TNK2CDK4CCND1CCNT1CDK9 | |
| SCHEMBL21373379 | 0.79 | WEE1 (0.51) | TNK2JAK2BRD4CDK4CCND1 | |
| SCHEMBL29506531 | 0.79 | CDK4 (0.55) | TNK2CDK4CCND1CCNT1CDK9 | |
| SCHEMBL21373412 | 0.79 | CDK4 (0.54) | TNK2BRD4CDK4CCND1WEE1 | |
| SCHEMBL21373434 | 0.78 | RPS6KA6 (0.58) | JAK2CDK4CCND1CCNT1CDK9 | |
| SCHEMBL21373461 | 0.78 | WEE1 (0.53) | TNK2JAK2CDK4CCND1CDK9 | |
| SCHEMBL21373409 | 0.78 | WEE1 (0.49) | TNK2JAK2BRD4CDK4CCND1 | |
| SCHEMBL21373334 | 0.78 | WEE1 (0.49) | TNK2JAK2BRD4CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118338905-A | Use of Wee1 kinase inhibitors in the treatment of cancer | 上海瑛派药业有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-117202908-A | Use of Wee1 kinase inhibitors in the treatment of cancer diseases | 上海瑛派药业有限公司 | 2023-12-08 | — | — | CN | claimed |
| WO-2023093840-A1 | USE OF WEE1 KINASE INHIBITORS IN THE TREATMENT OF CANCER | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2023-06-01 | — | — | WO | claimed |
| WO-2022188802-A1 | USE OF WEE1 KINASE INHIBITORS IN THE TREATMENT OF CANCER | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-09-15 | — | — | WO | claimed |
| CN-109906227-B | 8, 9-dihydroimidazo [1,2-a ] pyrimido [5,4-e ] pyrimidin-5 (6H) -ones | 上海瑛派药业有限公司 | 2022-03-11 | — | — | CN | claimed |
| WO-2025074275-A1 | COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS AND WEE1 INHIBITORS | REPARE THERAPEUTICS, INC. (CA) | 2025-04-10 | — | — | WO | disclosed |
| CN-118338905-A | Use of Wee1 kinase inhibitors in the treatment of cancer | 上海瑛派药业有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-117202908-A | Use of Wee1 kinase inhibitors in the treatment of cancer diseases | 上海瑛派药业有限公司 | 2023-12-08 | — | — | CN | disclosed |
| WO-2023093840-A1 | USE OF WEE1 KINASE INHIBITORS IN THE TREATMENT OF CANCER | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2023-06-01 | — | — | WO | disclosed |
| WO-2022188802-A1 | USE OF WEE1 KINASE INHIBITORS IN THE TREATMENT OF CANCER | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-09-15 | — | — | WO | disclosed |
| CN-109906227-B | 8, 9-dihydroimidazo [1,2-a ] pyrimido [5,4-e ] pyrimidin-5 (6H) -ones | 上海瑛派药业有限公司 | 2022-03-11 | — | — | CN | disclosed |