Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.48 |
| ▸ | HMGCR | P04035 | 5/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179774 | 0.95 | PTPN7 (0.45) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL6319883 | 0.88 | PTPN7 (0.47) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL11178915 | 0.86 | HMGCR (0.39) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL10725642 | 0.84 | HMGCR (0.39) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL23040316 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL11066113 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL10796010 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL1523678 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL9211891 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL11175213 | 0.84 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 464 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3348269-B1 | MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT | UNIV TSINGHUA (CN) | 2023-11-15 | — | — | EP | disclosed |
| EP-3250572-B1 | SUBSTITUTED IMIDAZO [1, 2-A]PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | SHANGHAI FUDAN ZHANGJIANG BIO PHARMACEUTICAL CO LTD (CN) | 2020-08-26 | — | — | EP | disclosed |
| EP-3698797-A1 | MEVALONIC ACID PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF | Tsinghua University (CN) | 2020-08-26 | — | — | EP | disclosed |
| EP-1551511-B1 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL MYERS SQUIBB CO (US) | 2018-10-24 | — | — | EP | disclosed |
| EP-3348269-A1 | MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT | Tsinghua University (CN) | 2018-07-18 | — | — | EP | disclosed |
| EP-2570414-B1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL MYERS SQUIBB CO (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2471773-B1 | Piperidinyl derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2016-03-23 | — | — | EP | disclosed |
| EP-2995615-A1 | CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND THEIR PHARMACEUTICAL USE | AstraZeneca AB (SE) | 2016-03-16 | — | — | EP | disclosed |
| EP-2173713-B1 | Piperidinyl derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2016-02-17 | — | — | EP | disclosed |
| EP-2558461-B1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL MYERS SQUIBB CO (US) | 2015-12-02 | — | — | EP | disclosed |
| US-H1679-H | Process for preparing an optically pure intermediate for a phosphonosulfonate soualene synthetase inhibitor | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| WO-1997026240-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |
| US-5543542-A | REACTING PHOSPHONOSULFONATE WITH OXIDIZING AGENT, REACTING PRODUCT WITH HYDROXYLAMINE PROTECTING AGENT, THEN WITH SILYL BROMIDE OR IODIDE | LAWRENCE R MICHAEL (US) | 1996-08-06 | — | — | US | disclosed |
| EP-0698609-A1 | Alpha-phosphorus substituted sulfinate derivatives as squalene synthetase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0643057-A1 | Inhibitors of microsomal triglyceride transfer protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-03-15 | — | — | EP | disclosed |
| EP-0601573-A1 | Alpha-phosphonocarboxylate squalene synthetase inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5312814-A | Antilipemic agents or anticholesterol agents | BRISTOL-MYERS SQUIBB CO. (US) | 1994-05-17 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0589473-A1 | Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and their use in pharmaceutical compositions | E.R. SQUIBB & SONS, INC. (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0570706-A1 | Aryl and heteroaryl (phosphinylmethyl) phosphonate squalene synthetase inhibitors and method | E.R. SQUIBB & SONS, INC. (US) | 1993-11-24 | — | — | EP | disclosed |