Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.76 |
| ▸ | CDK2 | P24941 | 20/20 | 0.76 |
| ▸ | CCND1 | P24385 | 16/20 | 0.76 |
| ▸ | CDK6 | Q00534 | 16/20 | 0.76 |
| ▸ | CDK4 | P11802 | 8/20 | 0.76 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.76 |
| ▸ | CDK9 | P50750 | 7/20 | 0.76 |
| ▸ | CCND3 | P30281 | 1/20 | 0.75 |
| ▸ | RB1 | P06400 | 1/20 | 0.69 |
| ▸ | CDK1 | P06493 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22164779 | 1.00 | CCNE1 (0.76) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29507883 | 0.99 | CCNE1 (0.75) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22860414 | 0.99 | CCNE1 (0.75) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22860530 | 0.98 | CCNE1 (0.73) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29508124 | 0.98 | CCNE1 (0.73) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22860395 | 0.93 | CCNE1 (0.66) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29507786 | 0.93 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22860648 | 0.93 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29507716 | 0.93 | CCNE1 (0.66) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22860118 | 0.92 | CCNE1 (0.64) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |