Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.63 |
| ▸ | CDK2 | P24941 | 6/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.63 |
| ▸ | CSF1R | P07333 | 5/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.63 |
| ▸ | CCND1 | P24385 | 4/20 | 0.63 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 2/20 | 0.63 |
| ▸ | CDK7 | P50613 | 2/20 | 0.63 |
| ▸ | CDK9 | P50750 | 2/20 | 0.63 |
| ▸ | CCNH | P51946 | 2/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.63 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22860387 | 1.00 | CDK4 (0.63) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22164826 | 0.95 | CDK4 (0.61) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22164823 | 0.95 | CDK4 (0.61) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22164902 | 0.90 | CDK4 (0.78) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL29507850 | 0.90 | CDK4 (0.78) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL29507838 | 0.90 | CDK4 (0.63) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22860486 | 0.90 | CDK4 (0.63) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22164819 | 0.88 | CDK4 (0.65) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL22165073 | 0.88 | CDK4 (0.65) | CDK4CDK6CDK2PIK3CDCSF1R | |
| SCHEMBL29507767 | 0.88 | CDK4 (0.65) | CDK4CDK6CDK2PIK3CDCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |