Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.74 |
| ▸ | DYRK2 | Q92630 | 15/20 | 0.74 |
| ▸ | DYRK1B | Q9Y463 | 15/20 | 0.74 |
| ▸ | DYRK3 | O43781 | 13/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.74 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.74 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.74 |
| ▸ | CDK9 | P50750 | 11/20 | 0.74 |
| ▸ | FYN | P06241 | 5/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.67 |
| ▸ | CDK2 | P24941 | 10/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102984 | 0.87 | FYN (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL102235 | 0.85 | DYRK1A (1.00) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL102940 | 0.85 | FYN (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL102656 | 0.83 | DYRK1A (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2947941 | 0.81 | DYRK1A (0.72) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16402788 | 0.81 | DYRK1A (0.51) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16402786 | 0.81 | DYRK1A (0.51) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16402787 | 0.81 | DYRK1A (0.51) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL102507 | 0.81 | FYN (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL18613549 | 0.81 | FYN (1.00) | DYRK1ADYRK2DYRK1BDYRK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200289606-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2020-09-17 | — | — | US | claimed |
| US-20190224270-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2019-07-25 | — | — | US | claimed |
| EP-3021862-B1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2017-08-30 | — | — | EP | claimed |
| US-20160166632-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2016-06-16 | — | — | US | claimed |
| EP-3021862-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | Onyx Therapeutics, Inc. (US) | 2016-05-25 | — | — | EP | claimed |
| WO-2015009888-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS, INC. (US) | 2015-01-22 | — | — | WO | claimed |
| US-12076363-B2 | Peptide epoxyketone proteasome inhibitors in combination with PIM kinase inhibitors for treatment of cancers | ONYX PHARMACEUTICALS, INC. (US) | 2024-09-03 | — | — | US | disclosed |
| US-20220265758-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS, INC. | 2022-08-25 | — | — | US | disclosed |
| US-11389440-B2 | PIM kinase inhibitors in combination with autophagy inhibitors for treatment of cancers | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3432886-B1 | PIM KINASE INHIBITORS IN COMBINATION WITH RNA SPLICING MODULATORS/INHIBITORS FOR TREATMENT OF CANCERS | UNIV MARYLAND (US) | 2021-06-02 | — | — | EP | disclosed |
| US-10842785-B2 | PIM kinase inhibitors in combination with RNA splicing modulators/inhibitors for treatment of cancers | THE UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200289606-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2020-09-17 | — | — | US | disclosed |
| US-20200289606-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2020-09-17 | — | — | US | disclosed |
| EP-3021862-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | Onyx Therapeutics, Inc. (US) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009888-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS, INC. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015009888-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS, INC. (US) | 2015-01-22 | — | — | WO | disclosed |
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200289606-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | PIM1, PIM2, PIM3 | DYRK1A 1532/4885DYRK2 1790/4885DYRK1B 1430/4885 |
| US-12076363-B2 | Peptide epoxyketone proteasome inhibitors in combination with PIM kinase inhibitors for treatment of cancers | PIM1, PIM2, PIM3 | DYRK1A 1532/4885DYRK2 1790/4885DYRK1B 1430/4885 |
| US-20160166632-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | PIM1, PIM2, PIM3 | DYRK1A 1532/4885DYRK2 1790/4885DYRK1B 1430/4885 |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | MAP4K2, MAP3K1, MAP3K2 | DYRK1A 461/4885DYRK2 336/4885DYRK1B 451/4885 |
| US-20190224270-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | PIM1, PIM2, PIM3 | DYRK1A 1532/4885DYRK2 1790/4885DYRK1B 1430/4885 |
| US-20220265758-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | PIM1, PIM2, PIM3 | DYRK1A 1532/4885DYRK2 1790/4885DYRK1B 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.