Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 13/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 13/20 | 0.50 |
| ▸ | MERTK | Q12866 | 13/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29065190 | 1.00 | CDK2 (0.59) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL24388620 | 0.86 | TYRO3 (0.54) | AXLTYRO3MERTKCDK19ALK | |
| SCHEMBL16513510 | 0.83 | CDK19 (0.68) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL29250619 | 0.83 | CDK19 (0.68) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL29507902 | 0.82 | JAK3 (0.59) | JAK1JAK3 | |
| SCHEMBL24388582 | 0.82 | JAK3 (0.59) | JAK1JAK3 | |
| SCHEMBL29507987 | 0.82 | CCNT1 (0.49) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL29065154 | 0.80 | ALK (0.68) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL29508053 | 0.79 | CDK2 (0.49) | CDK2CCNT1CCNE2CCNE1CDK9 | |
| SCHEMBL29507970 | 0.78 | CCNT1 (0.46) | CDK2CCNT1CCNE2CCNE1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237088-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |