SCHEMBL29508772

SCHEMBL29508772

CCOC(=O)C=Cc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 0.59
NR3C1 P04150 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1715658 1.00 AR (0.59) ARNR3C1
SCHEMBL1715902 1.00 AR (0.59) ARNR3C1
SCHEMBL20003376 0.91 AR (0.48) ARNR3C1
SCHEMBL1715349 0.88 AR (0.63) ARNR3C1
SCHEMBL30184880 0.88 AR (0.63) ARNR3C1
SCHEMBL1715352 0.88 AR (0.63) ARNR3C1
SCHEMBL1715910 0.87 AR (0.62) ARNR3C1
SCHEMBL1715911 0.87 AR (0.62) ARNR3C1
SCHEMBL30184868 0.87 AR (0.62) ARNR3C1
SCHEMBL7031743 0.86 AR (0.69) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116003328-A Diaryl hydantoin compounds 加利福尼亚大学董事会 2023-04-25 CN disclosed
CN-110003114-B Diarylhydantoin compounds 加利福尼亚大学董事会 2023-01-17 CN disclosed
EP-3970721-A1 DIARYLHYDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR ANTAGONISTS FOR TREATMENT OF CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-23 EP disclosed