SCHEMBL29514949

SCHEMBL29514949

Cc1c(-c2nc(Nc3ccc(N4CC5(CN(C)CC5(F)F)C4)cn3)ncc2F)sc2c1nc(C)n2C(C)C

nearest known ligand 0.78

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCND1 P24385 17/20 0.78
CDK4 P11802 13/20 0.78
CDK6 Q00534 9/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29515005 0.88 CCND1 (1.00) CCND1CDK4CDK6
SCHEMBL29515081 0.86 CCND1 (0.79) CCND1CDK4CDK6
SCHEMBL25235418 0.86 CCND1 (0.79) CCND1CDK4CDK6
SCHEMBL24322348 0.84 CCND1 (0.84) CCND1CDK4CDK6
SCHEMBL25285212 0.84 CCND1 (0.79) CCND1CDK4CDK6
SCHEMBL29515132 0.84 CCND1 (0.79) CCND1CDK4CDK6
SCHEMBL24322347 0.82 CCND1 (0.84) CCND1CDK4CDK6
SCHEMBL29514918 0.82 CCND1 (0.84) CCND1CDK4CDK6
SCHEMBL25284787 0.82 CCND1 (0.76) CCND1CDK4CDK6
SCHEMBL29514856 0.82 CCND1 (0.76) CCND1CDK4CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4214213-A1 CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS Prelude Therapeutics, Incorporated (US) 2023-07-26 EP claimed
WO-2022061273-A1 CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS PRELUDE THERAPEUTICS, INCORPORATED (US) 2022-03-24 WO claimed
EP-4214213-A1 CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS Prelude Therapeutics, Incorporated (US) 2023-07-26 EP disclosed
WO-2022061273-A1 CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS PRELUDE THERAPEUTICS, INCORPORATED (US) 2022-03-24 WO disclosed