Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 19/20 | 1.00 |
| ▸ | CDK4 | P11802 | 14/20 | 1.00 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.71 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | STK16 | O75716 | 1/20 | 0.50 |
| ▸ | CCNK | O75909 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24322192 | 1.00 | CCND1 (1.00) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL24322347 | 0.89 | CCND1 (0.84) | CCND1CDK4CDK6CCNA2CDK2 | |
| SCHEMBL29514918 | 0.89 | CCND1 (0.84) | CCND1CDK4CDK6CCNA2CDK2 | |
| SCHEMBL29515160 | 0.85 | CCND1 (0.75) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL24322997 | 0.85 | CCND1 (0.75) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL24322185 | 0.85 | CCND1 (0.75) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL29515035 | 0.83 | CCND1 (1.00) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL25284830 | 0.83 | CCND1 (1.00) | CCND1CDK4CDK6CITGAK | |
| SCHEMBL25284787 | 0.83 | CCND1 (0.76) | CCND1CDK4CDK6CCNA2CDK2 | |
| SCHEMBL29514856 | 0.83 | CCND1 (0.76) | CCND1CDK4CDK6CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214213-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | Prelude Therapeutics, Incorporated (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022061273-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2022-03-24 | — | — | WO | disclosed |